To be fair, Ugly Betty began in latin america where stereotypes run rampant about gay males and beautiful women. It's set in a women's fashion magazine headquarters where physical beauty is highly valued. The intent is to bust the stereotypes by exaggerating them in this showcase of extremes. I understand that in latin america it was limited to one or two seasons as it's story was resolved in that length of time and they did not seek to find ways to extend it just becasue it was commercially popular. I've not watched it often, but if her homelife is also at issue and involves a single mom sister, I'd venture a guess that this is part of the hollywood twist to the storyline... added for the purpose of stretching it into infinity if the opportunity arose to make more $$ from the effort.
I'm actually not so troubled by the image of bitchy versus ugly women heads of business, as I am by the very poor image of fathers. And you're right that 2 & a half men show also seems like the guys involved are a couple of bumbling fools... the skirt chasing man-bo and his socially inept brother.
It might be a good idea to have someone interested in this subject contact the writers for some of these sitcoms, as well as the producers. Not that we would ever be able to get a return to the Father Knows Best type of father, but maybe we could help them find a commercially viable STRONG father type who had a brain and couldu manage social issues without being gay.